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Coffee also helps to release gastrin, a hormone that plays a role in the motility of the intestinal tract. Additionally, according to a study published in 1990 in Gut , a journal of gastroenterology, researchers found that coffee induces a gastrocolonic response in some individuals just minutes after they consume the beverage, per a Live Science report

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

An important observation in this study was that the quantities of all the mentioned MMPs were greatly increased in the presence of both keratinocytes and fibroblasts, showing the importance of the crosstalk between keratinocytes and fibroblasts in MMP production, and thus the relevance of a bilayer skin model